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Intolerances

Gut microbiota and metabolism

Pathogens and infections

Chapters that readers rate at 4 out of 5 stars or more on average for this question. An average only exists from 3 ratings. You can choose several.

Opportunistic pathogens

Germs that only become a problem when the balance is off. 3 chapters – expand
  • Level:Intermediate After antibiotics: C. difficile and faecal transplants A germ that can take over after antibiotics, and a treatment that works better than any drug. AntibioticsFaecal transplantProbioticsDiarrhoeaGut infectionsBile acidsToxins and mould Established How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
  • Level:Intermediate When the gut does not settle after an infection Stomach bug, food poisoning, traveller's diarrhoea: why symptoms sometimes stay. Gut infectionsIBSDiarrhoeaBile acids Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
  • Level:Intermediate Saccharomyces boulardii: the probiotic yeast Why a yeast survives antibiotics, what it is proven to help with, and when it can become dangerous. ProbioticsAntibioticsDiarrhoeaGut infections Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community

Digestive function

Stomach acid, bile and enzymes as groundwork for the gut. 1 chapter – expand
  • Level:Intermediate Acid blockers (PPIs): what they change in the gut and how to stop them properly Proton pump inhibitors are among the most widely used medicines in the world. They are very effective for reflux and ulcers, but change the gut flora and nutrient absorption. What is established, what is not, and how to stop them. Acid blockersMedicationGut infectionsAllergies Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.