What changed?

Which chapters were revised when, and why: new studies, notes from users or expert review.

    • Corrected

      The evidence ratings of the test phases have been reviewed. They show how well it is established that a change relieves gut symptoms, not whether it is healthy in general. Rated higher: psyllium husk (5, recommended by guidelines), less fructose and sorbitol (3, small blinded studies), no alcohol (3, consistent observational studies) and regular meals without snacks (2, established physiology).

    • Updated

      The chapter on the Herxheimer reaction now also covers triggers beyond antibiotics: strong probiotics and ferments such as milk kefir from grains, faecal microbiota transplants, herbal cures and antifungal drugs. It explains why early symptoms usually have ordinary causes and describes genuine reactions to dying parasites in tissue. Plus a new tip on starting strong ferments slowly.

      Herxheimer reaction, die-off and toxins

    • New feature

      With an account you can save tips: next to every tip under “What often helps” there is a small +. One click adds the tip to your test phases, a − removes it again. The test phases page lists all saved tips by chapter and type (lifestyle, supplements, medical), and where a matching template exists, you can evaluate the tip right away as a test phase with the diary. Only you can see what you save.

    • New

      New chapter “Autoimmune diseases and the gut”: how the immune system learns tolerance in the gut, what studies on the gut microbiome show in Hashimoto's, autoimmune gastritis, type 1 diabetes, vitiligo, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, lupus and alopecia areata, and where there are only animal studies. Also why coeliac disease and autoimmune gastritis are more common with Hashimoto's and type 1 diabetes, what disturbs the absorption of thyroid tablets, and what the evidence says about vitamin D, selenium and a gluten-free diet. The chapter is part of the problem tree and is recommended in the gut check when an autoimmune disease is reported.

      Autoimmune diseases and the gut: Hashimoto's, vitiligo, type 1 diabetes and more,Immune system and inflammation,Lactose, fructose, gluten: making sense of intolerances,Stomach acid, bile and enzymes,Nutrient deficiency in gut problems: when food no longer arrives

    • New

      New chapter “PEA (palmitoylethanolamide)”: how this fatty substance made by the body calms mast cells, glial cells and inflammation in the gut, what the two IBS trials with PEA and polydatin show, how good the evidence for pain is and what is known about safety with longer use. Cross-links from the chapters on mast cells and abdominal pain.

      PEA (palmitoylethanolamide): the body's own inflammation brake in a capsule,Mast cells: alarm cells in the gut, histamine and the disputed MCAS,Abdominal pain and cramps: where the pain comes from

    • Updated

      The sweetener paragraphs now also say what each substance does to the gut microbiome. Sucralose reaches the large intestine largely unchanged; large reviews of randomised trials find no clear average change there, but individual studies and animal experiments do. Saccharin is the substance behind the oldest microbiome finding (2014). Aspartame was considered unremarkable because it is broken down early, yet it still changed the microbiome in the 2022 study. Gut bacteria can break down acesulfame K; for cyclamate, dedicated microbiome studies are lacking. For stevia there is the additional finding that stevia and rebaudioside A wake dormant bacteriophages inside gut bacteria and change their infectivity. In the large intestine, sugar alcohols are food for the bacteria – erythritol promoted butyrate production in a gut model, while sorbitol promoted inflammatory signals in a mouse study.

      Sweeteners and sugar alcohols

    • Updated

      The sweetener chapter now introduces the individual substances: sucralose, saccharin, aspartame, stevia, acesulfame K, cyclamate and neotame as well as the sugar alcohols sorbitol, xylitol, maltitol, isomalt, lactitol, mannitol and erythritol — each with its E number, typical products (zero drinks, chewing gum, protein bars, table-top sweeteners) and whether it reaches the large intestine. The salt forms sodium cyclamate and sodium saccharin are named as well, because that is how they appear on the ingredients list. It also notes that “naturally sweetened” with honey or agave syrup is no progress for the gut, adds a tip on the amount and covers the 2023 WHO guideline.

      Sweeteners and sugar alcohols

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