Saving The Gut Together
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Gut-brain axis

How stress, sleep and nerves steer digestion. 1 chapter – expand
  • Level:Expert POTS and hypermobility: when circulation and connective tissue drag the gut along People with hypermobile joints (hEDS, hypermobility spectrum) or a racing heart on standing (POTS) have gut symptoms strikingly often. What studies show, what to make of the much-quoted "trifecta" with MCAS, and what helps. IBSConstipationExerciseHistamine Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community