Saving The Gut Together
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Immune system and inflammation

The gut as the body's largest immune organ. 1 chapter – expand
  • Level:Expert Mast cells: alarm cells in the gut, histamine and the disputed MCAS Mast cells sit just beneath the gut lining and release histamine when alarmed. What they have to do with IBS and stress, and why mast cell activation syndrome is so often wrongly diagnosed. HistamineIBSStressAllergies Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community