Saving The Gut Together
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Immune system and inflammation

The gut as the body's largest immune organ. 1 chapter – expand
  • Level:Intermediate PEA (palmitoylethanolamide): the body's own inflammation brake in a capsule A fatty substance the body makes itself to calm mast cells and inflammation. As a supplement it is taken for gut and nerve pain. What studies show and where they are thin. IBSInflammationHistamineDiarrhoea Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.