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Digestive function

Stomach acid, bile and enzymes as groundwork for the gut. 1 chapter – expand
  • Level:Intermediate Nutrient deficiency in gut problems: when food no longer arrives Why gut symptoms can leave you short of iron, vitamin B12, vitamin D, the fat-soluble vitamins and zinc, how to read blood results correctly and when supplements really help. NutrientsVitamins and fatty acidsDiarrhoeaTests and diagnosticsBody weight Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.

Immune system and inflammation

The gut as the body's largest immune organ. 1 chapter – expand
  • Level:Intermediate Crohn’s disease and ulcerative colitis: understanding inflammatory bowel disease In Crohn’s disease and ulcerative colitis, the immune system permanently attacks the gut wall. What distinguishes the two, what role genes, smoking, antibiotics and gut microbiota play, why early treatment matters, and what diet, probiotics and faecal transplants really achieve. InflammationDiarrhoeaTests and diagnosticsMedicationAntibioticsNutrientsProbioticsFaecal transplantMediterranean diet Established How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.