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Microbial diversity

Why many different species keep the gut stable. 1 chapter – expand
  • Level:Beginner For everyone Your gut in ten minutes Who lives there, what do they do, and why is balance more important than individual germs? FibrePlant diversityFermented foodsAntibioticsExerciseTests and diagnostics Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.

Gut-brain axis

How stress, sleep and nerves steer digestion. 1 chapter – expand
  • Level:Beginner The gut-brain axis How stress hits the stomach and why psychotherapy works for IBS. StressIBSPsychotherapyExercise Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.

Digestive function

Stomach acid, bile and enzymes as groundwork for the gut. 4 chapters – expand
  • Level:Beginner Constipation: more than too little fibre Kiwifruit, psyllium, pelvic floor and methane: what is behind sluggish digestion. ConstipationFibreExerciseMedication Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
  • Level:Beginner Heartburn and reflux When acid rises: what helps, when acid blockers make sense and when to stop them. Acid blockersMedicationSleep Established How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
  • Level:Beginner Diverticula, haemorrhoids and fissures: what can go wrong at the end of the gut Three common problems in the lower gut that people rarely talk about. Why nuts and seeds are fine with diverticula, why mild diverticulitis often heals without antibiotics, and what your phone on the toilet has to do with haemorrhoids. FibreConstipationInflammationAntibiotics Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
  • Level:Beginner Diarrhoea: understand it, place it and react the right way Watery, urgent, acute or chronic: the four mechanisms, the most common causes and when it needs checking by a doctor. DiarrhoeaIBSFODMAPBile acidsGut infectionsTests and diagnosticsTravel Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.