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Gut barrier

The gut lining as the border between gut contents and the body. 1 chapter – expand
  • Level:Intermediate The “leaky gut stack”: colostrum, zinc carnosine, aloe and co. What goes into the typical gut-lining blends, what studies show and where the risks lie. Vitamins and fatty acidsMedicationIBSInflammationExercise Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community

Gut-brain axis

How stress, sleep and nerves steer digestion. 1 chapter – expand
  • Level:Intermediate Brain fog and fatigue: when your gut makes your head tired Many people with gut problems feel exhausted and foggy. What studies show, which causes can be checked and what is mere speculation. SleepVitamins and fatty acidsCoeliac disease and glutenInflammationProbioticsTests and diagnostics Promising How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community

Digestive function

Stomach acid, bile and enzymes as groundwork for the gut. 1 chapter – expand
  • Level:Intermediate Nutrient deficiency in gut problems: when food no longer arrives Why gut symptoms can leave you short of iron, vitamin B12, vitamin D, the fat-soluble vitamins and zinc, how to read blood results correctly and when supplements really help. NutrientsVitamins and fatty acidsDiarrhoeaTests and diagnosticsBody weight Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.

Immune system and inflammation

The gut as the body's largest immune organ. 1 chapter – expand
  • Level:Intermediate Autoimmune diseases and the gut: Hashimoto's, vitiligo, type 1 diabetes and more When the immune system attacks the body itself, the gut is often involved – as the place where the immune system learns, as a bystander that gets hit, and perhaps as a co-trigger. What is established, what has only been shown in mice, and what people affected can actually do. InflammationCoeliac disease and glutenVitamins and fatty acidsMedicationTests and diagnostics Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community