Chapters
Take the gut check and we will sort the chapters by relevance for you.
Opportunistic pathogens
Germs that only become a problem when the balance is off. 2 chapters – expand
- Level:Intermediate Opportunistic pathogens Germs that are always there and only become a problem when the balance tips. AntibioticsAcid blockersMedicationProbioticsGut infectionsInflammationTests and diagnostics Promising How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
- Level:Intermediate Mouth and gut: how teeth, gums and mouthwash touch the gut flora Every day we swallow billions of mouth bacteria. Usually this is harmless, but with inflamed gums, acid blockers or a weakened gut flora, some of them settle in the gut. Mouth and teethAcid blockersInflammation Plausible How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
Microbial diversity
Why many different species keep the gut stable. 1 chapter – expand
- Level:Intermediate Medications that change the gut Not just antibiotics: acid blockers, metformin, painkillers and others affect the gut microbiota. MedicationAcid blockersAntibioticsAntibiotic resistance Promising How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
Digestive function
Stomach acid, bile and enzymes as groundwork for the gut. 4 chapters – expand
- Level:Intermediate Stomach acid, bile and enzymes The groundwork in the stomach and small intestine determines what reaches the large intestine. Acid blockersMedicationBile acidsAlcoholBloatingTests and diagnostics Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
- Level:Intermediate Sensitive stomach: fullness, upper abdominal pain and Helicobacter What is behind upper abdominal symptoms when the endoscopy is normal, why the Helicobacter test comes first and what else helps. BloatingIBSAcid blockersTests and diagnostics Promising How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
- Level:Intermediate Acid blockers (PPIs): what they change in the gut and how to stop them properly Proton pump inhibitors are among the most widely used medicines in the world. They are very effective for reflux and ulcers, but change the gut flora and nutrient absorption. What is established, what is not, and how to stop them. Acid blockersMedicationGut infectionsAllergies Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
- Level:Intermediate The digestive chain: how stomach acid, bile and pancreas set each other off Digestion is a relay race: the head starts, the acid passes the signal to the duodenum, hormones call up bile and enzymes. Who sends which signal, and what happens when one link is weak. Bile acidsAcid blockers Well supported How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open.
Immune system and inflammation
The gut as the body's largest immune organ. 1 chapter – expand
- Level:Intermediate Allergies and intolerances: how the gut learns to tolerate food Every day the gut has to tolerate foreign protein. How this tolerance develops, what role bacteria, stomach acid and skin play, and why many people feel allergic without being so. AllergiesProbioticsAcid blockersAntibioticsTests and diagnostics Promising How we rate the evidence Established Recommended in medical guidelines or supported by several consistent meta-analyses of randomised human studies. Well supported Several randomised studies in humans with largely consistent results. Promising Single randomised or controlled studies in humans, not yet independently confirmed — or many consistent observational studies. Plausible Two cases: first observational or pilot studies with small samples — or a settled basis that is not in dispute, such as movement, sleep or meal pauses. But not tested in humans for symptoms. Experimental Barely studied in humans. Mainly lab and animal studies or theoretical reasoning; whether it helps is open. Community